4 ms·

Observational study shows low dose aspirin users had 47% lower Covid death rate

4 points by briefcomment 6y ago

briefcomment 6y ago
" "This is a critical finding that needs to be confirmed through a randomized clinical trial," said study leader Jonathan Chow, MD, Assistant Professor of Anesthesiology at UMSOM. "If our finding is confirmed, it would make aspirin the first widely available, over-the-counter medication to reduce mortality in COVID-19 patients." "
tboyd47 6y ago
Mediating variables?
JoeAltmaier 6y ago
Is it the aspirin? Or the underlying condition that stimulated the use of aspirin? I see they tried to control for those. So it seems real.
thro1 6y ago
Similar topic discussed here 7 months ago: https://news.ycombinator.com/item?id=22702941 https://news.ycombinator.com/item?id=22702941 ('D, L-lysine acetylsalicylate and glycine Impairs Coronavirus Replication (2016) [pdf]') from this topic https://news.ycombinator.com/item?id=22703132 https://news.ycombinator.com/item?id=22703132 summarizes: > According to the Medcram youtube series, NSAIDs in general are known to impair virus replication, but also impair immune function. What is the net result? That is less clear. Many believe that aspirin had a negative effect during the 1918 flu epidemic though. I remember (can't find sources now) that paracetamol is considered as safe, but aspirin has to many different workings, factors or interactions to be considered - when it may help or quite the opposite. BTW. https://doi.org/10.1002/jmv.26514 https://doi.org/10.1002/jmv.26514 ('Lowering the transmission and spread of human coronavirus'), referenced once on HN, has a table with 'nasal rinse and mouthwash gargling product's ingredients' - the best one working is Listerine Antiseptic with active ingredients (one is salicylate): Eucalyptol (0.092%) Menthol (0.042%) Methyl Salicylate (0.06%) Thymol (0.064%) Regarding salicylates (with inhalations as my personal point of view), I found out mostly about their toxicity and higher doses, except the following (2011): https://erj.ersjournals.com/content/38/Suppl_55/p825.abstract https://erj.ersjournals.com/content/38/Suppl_55/p825.abstrac... ('Aspirin inhalation treatment for COPD* patients: Preliminary studies on PK and inflammatory biomarkers') - could it somehow be relevant ((anti-inflammatory, breath-helping and.. virus killing))? (* Chronic Obstructive Pulmonary Disease, makes it harder to breathe, top reason Long-term exposure to chemical irritants as smoking)

4 points by briefcomment 6y ago

" "This is a critical finding that needs to be confirmed through a randomized clinical trial," said study leader Jonathan Chow, MD, Assistant Professor of Anesthesiology at UMSOM. "If our finding is confirmed, it would make aspirin the first widely available, over-the-counter medication to reduce mortality in COVID-19 patients." "

tboyd47 6y ago

Mediating variables?

JoeAltmaier 6y ago

Is it the aspirin? Or the underlying condition that stimulated the use of aspirin? I see they tried to control for those. So it seems real.

thro1 6y ago

Similar topic discussed here 7 months ago: https://news.ycombinator.com/item?id=22702941 https://news.ycombinator.com/item?id=22702941 ('D, L-lysine acetylsalicylate and glycine Impairs Coronavirus Replication (2016) [pdf]') from this topic https://news.ycombinator.com/item?id=22703132 https://news.ycombinator.com/item?id=22703132 summarizes: > According to the Medcram youtube series, NSAIDs in general are known to impair virus replication, but also impair immune function. What is the net result? That is less clear. Many believe that aspirin had a negative effect during the 1918 flu epidemic though. I remember (can't find sources now) that paracetamol is considered as safe, but aspirin has to many different workings, factors or interactions to be considered - when it may help or quite the opposite. BTW. https://doi.org/10.1002/jmv.26514 https://doi.org/10.1002/jmv.26514 ('Lowering the transmission and spread of human coronavirus'), referenced once on HN, has a table with 'nasal rinse and mouthwash gargling product's ingredients' - the best one working is Listerine Antiseptic with active ingredients (one is salicylate): Eucalyptol (0.092%) Menthol (0.042%) Methyl Salicylate (0.06%) Thymol (0.064%) Regarding salicylates (with inhalations as my personal point of view), I found out mostly about their toxicity and higher doses, except the following (2011): https://erj.ersjournals.com/content/38/Suppl_55/p825.abstract https://erj.ersjournals.com/content/38/Suppl_55/p825.abstrac... ('Aspirin inhalation treatment for COPD* patients: Preliminary studies on PK and inflammatory biomarkers') - could it somehow be relevant ((anti-inflammatory, breath-helping and.. virus killing))? (* Chronic Obstructive Pulmonary Disease, makes it harder to breathe, top reason Long-term exposure to chemical irritants as smoking)