I don't know whether that has changed, but in an old startup I worked at(20 years ago) a tool similar to simulink was used to simulate a wireless chip design ov

I don't know whether that has changed, but in an old startup I worked at(20 years ago) a tool similar to simulink was used to simulate a wireless chip design over it's development life, a few years. And in simulation you try/change things often. It seems to work well. There, change happen over the many system parameters, small blocks(some written in code), or maybe adding a new block(but those systems are dataflow like, and without that many unique blocks, so it's the right abstraction)