3 ms·

> I'm assuming you also don't know if you got the active substance or a placebo? Yep. In the UK, they used an existing, unrelated vaccine with similar side eff

> I'm assuming you also don't know if you got the active substance or a placebo? Yep. In the UK, they used an existing, unrelated vaccine with similar side effects as the control so it wasn't obvious which one you got. In some countries and for some of the other vaccine trials, they are just using saline as the control so it seems like a lot of those people would know.

LandR 6y ago
> so it seems like a lot of those people would know. You can tell the difference in getting a vaccine shot and a shot of saline?
- garmaine 6y ago
  You ever gotten a flu shot? Usually your arm hurts for a day or two after, even if there are no other symptoms. This is a side effect of the immune response, as your body fights the "infection" at the point of injection.
  - comfydragon 6y ago
    And here I've thought the sore arm was your body reacting to a hypodermic needle going into your upper arm muscles. I suppose it could be a little of both though?
- freeone3000 6y ago
  Many people get an immune reaction to the flu vaccine and this vaccine - mild flu-like symptoms for a day or two.
- jleahy 6y ago
  Yes, the vaccine you'll feel a bit rough for a few days after (potentially). The saline you won't.
- deleted 6y ago
  [deleted]
- raverbashing 6y ago
  You can Some trials are going to use an unrelated vaccine as placebo (I think they're using a Meningitis one)
- tialaramex 6y ago
  I don't get any difference, though I do always get warned about this (I qualify for a free flu jab every year because part of my immune system had cancer when was I was younger) This year I actually had a moment as I was preparing for bed that night when I went "Oh shit what's this?" because I felt a bump that hadn't been there before on one arm. It was the tiny sticking plaster the nurse applied after the injection to cover the site. That was the first time since leaving the clinic I'd even remembered I got a jab that day. I peeled it off, put it in the waste and went to bed. A lot of the things that happen are psychosomatic, so those would happen even if it was saline (or, I suppose they might not happen if you believe it was just saline even if it was really the active vaccine) but there are effects above this baseline in some people some of the time.
deleted 6y ago
[deleted]

LandR 6y ago

> so it seems like a lot of those people would know. You can tell the difference in getting a vaccine shot and a shot of saline?

garmaine 6y ago
You ever gotten a flu shot? Usually your arm hurts for a day or two after, even if there are no other symptoms. This is a side effect of the immune response, as your body fights the "infection" at the point of injection.
- comfydragon 6y ago
  And here I've thought the sore arm was your body reacting to a hypodermic needle going into your upper arm muscles. I suppose it could be a little of both though?
freeone3000 6y ago
Many people get an immune reaction to the flu vaccine and this vaccine - mild flu-like symptoms for a day or two.
jleahy 6y ago
Yes, the vaccine you'll feel a bit rough for a few days after (potentially). The saline you won't.
deleted 6y ago
[deleted]
raverbashing 6y ago
You can Some trials are going to use an unrelated vaccine as placebo (I think they're using a Meningitis one)
tialaramex 6y ago
I don't get any difference, though I do always get warned about this (I qualify for a free flu jab every year because part of my immune system had cancer when was I was younger) This year I actually had a moment as I was preparing for bed that night when I went "Oh shit what's this?" because I felt a bump that hadn't been there before on one arm. It was the tiny sticking plaster the nurse applied after the injection to cover the site. That was the first time since leaving the clinic I'd even remembered I got a jab that day. I peeled it off, put it in the waste and went to bed. A lot of the things that happen are psychosomatic, so those would happen even if it was saline (or, I suppose they might not happen if you believe it was just saline even if it was really the active vaccine) but there are effects above this baseline in some people some of the time.

deleted 6y ago

[deleted]