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> It uses a weakened live virus that can (and apparently has, in the case of the J&J vaccine, which is using very similar tech) cause serious adverse systemic r

> It uses a weakened live virus that can (and apparently has, in the case of the J&J vaccine, which is using very similar tech) cause serious adverse systemic reactions. There is no evidence to prove the vaccine has caused any serious adverse effects so far. If that were the case, it is unlikely the Data Safety and Monitoring Board (DSMB) and U.S. Food and Drug Administration (FDA) would recommend resuming the trial. > After a thorough evaluation of a serious medical event experienced by one study participant, no clear cause has been identified. There are many possible factors that could have caused the event. Based on the information gathered to date and the input of independent experts, the Company has found no evidence that the vaccine candidate caused the event. https://www.jnj.com/our-company/johnson-johnson-prepares-to-resume-phase-3-ensemble-trial-of-its-janssen-covid-19-vaccine-candidate-in-the-us https://www.jnj.com/our-company/johnson-johnson-prepares-to-...

aphextron 6y ago
>There is no evidence to prove the vaccine has caused any serious adverse effects so far. If that were the case, it is unlikely the Data Safety and Monitoring Board (DSMB) and U.S. Food and Drug Administration (FDA) would recommend resuming the trial. There's also no evidence to prove that it wasn't. Furthermore, the AstraZeneca vaccine was halted for a case of transverse myelitis, a very common (and serious) adverse reaction seen in DNA/adenovirus based vaccines like ChAdOx1 [0]. These complications have not been seen at all in the mRNA based vaccines, since they do not involve a live virus. [0] https://medcitynews.com/2020/10/report-fda-takes-closer-look-at-adverse-event-that-occurred-in-astrazeneca-covid-19-vaccine-study/#:~:text=Regulators%20in%20the%20U.S.%20are,according%20to%20a%20news%20report.&text=The%20vaccine%2C%20AZD1222%2C%20originated%20at,known%20as%20ChAdOx1%20nCoV%2D19 https://medcitynews.com/2020/10/report-fda-takes-closer-look....
- RobertDeNiro 6y ago
  Transverse myelitis was also observed in some people infected by sars-cov-2, one case alone is not enough to lead to any meaningful conclusion.
- MrAlex94 6y ago
  Well, we won't find out until the trials end, but why would they have been approved to continue by safety boards if that wasn't the case? Also, the AZ trial was given the go-ahead along with the J&J trial. https://www.reuters.com/article/us-health-coronavirus-astrazeneca-usa-idUSKBN2782KF https://www.reuters.com/article/us-health-coronavirus-astraz...

aphextron 6y ago

>There is no evidence to prove the vaccine has caused any serious adverse effects so far. If that were the case, it is unlikely the Data Safety and Monitoring Board (DSMB) and U.S. Food and Drug Administration (FDA) would recommend resuming the trial. There's also no evidence to prove that it wasn't. Furthermore, the AstraZeneca vaccine was halted for a case of transverse myelitis, a very common (and serious) adverse reaction seen in DNA/adenovirus based vaccines like ChAdOx1 [0]. These complications have not been seen at all in the mRNA based vaccines, since they do not involve a live virus. [0] https://medcitynews.com/2020/10/report-fda-takes-closer-look-at-adverse-event-that-occurred-in-astrazeneca-covid-19-vaccine-study/#:~:text=Regulators%20in%20the%20U.S.%20are,according%20to%20a%20news%20report.&text=The%20vaccine%2C%20AZD1222%2C%20originated%20at,known%20as%20ChAdOx1%20nCoV%2D19 https://medcitynews.com/2020/10/report-fda-takes-closer-look....

RobertDeNiro 6y ago
Transverse myelitis was also observed in some people infected by sars-cov-2, one case alone is not enough to lead to any meaningful conclusion.
MrAlex94 6y ago
Well, we won't find out until the trials end, but why would they have been approved to continue by safety boards if that wasn't the case? Also, the AZ trial was given the go-ahead along with the J&J trial. https://www.reuters.com/article/us-health-coronavirus-astrazeneca-usa-idUSKBN2782KF https://www.reuters.com/article/us-health-coronavirus-astraz...