For me the most important factor against using a laptop is cooling. With a desktop you can go to the extremes and install water cooling. With a laptop you're al

For me the most important factor against using a laptop is cooling. With a desktop you can go to the extremes and install water cooling. With a laptop you're always compromising on performance because if the load gets high the processor starts throttling and thus its performance is severely reduced. As a side effect there's also the issue with noise. A laptop fan is way more noisy than a desktop one because there's so much more space inside the box.