The paper Atomic-resolution protein structure determination by cryo-EM [1]: > Single-particle electron cryo-microscopy (cryo-EM) is a powerful method for solvi

The paper Atomic-resolution protein structure determination by cryo-EM [1]: > Single-particle electron cryo-microscopy (cryo-EM) is a powerful method for solving the three-dimensional structures of biological macromolecules. > At resolutions better than 4 Å, atomic model building starts to become possible, but the direct visualization of true atomic positions in protein structure determination requires much higher (better than 1.5 Å) resolution, which so far has not been attained by cryo-EM. > Here we report a 1.25 Å-resolution structure of apoferritin obtained by cryo-EM with a newly developed electron microscope that provides, to our knowledge, unprecedented structural detail. [1] https://www.nature.com/articles/s41586-020-2833-4 https://www.nature.com/articles/s41586-020-2833-4