3 ms·
Next, researchers will strive to achieve similar sharp resolution with less rigid, large protein complexes, such as the spliceosome Does this mean we don't cur
by sp332 6y ago
Next, researchers will strive to achieve similar sharp resolution with less rigid, large protein complexes, such as the spliceosome
Does this mean we don't currently have a good picture of what the spliceosome looks like? That seems important!
- Nth_step 6y agoWe do. For the entire splicing cycle, via cryoEM: "Molecular Mechanisms of Splicing: Spliceosome Machinery and Pre-Messenger RNA Splicing Cycle" https://youtube.com/watch?v=OuAGeQYjfus https://youtube.com/watch?v=OuAGeQYjfus
- natechols 6y agoMost of these still count as low-resolution - I don't see anything better than 3 Angstrom in the PDB, most are much worse. More than good enough for movies and functional assays, but some of the fine details will be guesses.