In this case it's a little like finding someone's house in a town you've never been in before. You expect the town's map to be accurate and to have all relevant

In this case it's a little like finding someone's house in a town you've never been in before. You expect the town's map to be accurate and to have all relevant streets listed - not having some of them missing. This report suggests that we do have 'streets' missing. Researchers are now delving into finely nuanced areas of research at a level the equivalent of the house before the preliminaries are resolved - before all streets are found. Bypassing prerequisites always has serious consequences, things go wrong, errors occur, time is wasted, work is duplicated by others, etc. Even patients may die. I'd suggest that no one yet knows how this will impact research that's already been completed and which now has to be reinvestigated.