4 ms·
not even two months ago there was a big HN discussion about a blog post, including comments here by the author: https://www.devaboone.com/post/vitamin-d-part-2
by zzzeek 6y ago
not even two months ago there was a big HN discussion about a blog post, including comments here by the author:
https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-story?postId=5f39453f8d01fe00170023fe https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st...
which would appear to contradict this article quite directly, if I'm reading correctly (I'm a know-nothing here taking 2000 iu /day, just trying to understand the topic)?
"Her Vitamin D was low at the time, so her physician started her on over-the-counter Vitamin D supplementation at 5000 international units (IUs) daily. Five years later, she was still on this dose, and her blood Vitamin D level had risen to 79 ng/ml. This level is within what many labs call the normal range, between 30 and 100 ng/ml, but levels above 70 are almost always a result of high dose supplementation, and I have seen toxicity with levels between 70 and 100 ng/ml. (A better “normal range” based on what I have seen would probably be between 30 and 60.) "
The linked article seems to be using nmol/L units as opposed to ng/ml so multiplying by 2.5 doesnt seem to be working out for me, someone who knows something have any comparison between these two?
- R0b0t1 6y ago5000IU is a rather large dose and her dosage was not adjusted. Beware of that author's potential biases: doctors are heavily invested in getting you to pay them more money even though they might cite humanitarian (and very patronizing) reasons for doing so. But, having vitamin D be easily accessible may be the better course of action. A similar scenario is sceen in India where most antibiotics are available OTC, something "unthinkable" in the US.
- WillPostForFood 6y agoAlso note that the patient was in Arizona, and may already have been getting a good amount of vitamin D from sun exposure.
- ColanR 6y agoNot sure why you're getting downvoted. It's definitely important to be aware of potential biases.
- jjeaff 6y agoProbably because I think the science on avoiding too many antibiotics in a population is pretty well settled. Too many antibiotics will lead to more antibiotic resistant bacterial outbreaks.
- R0b0t1 6y agoYes and no. Realize most problem areas are hospitals and factory farms where antibiotics are everpresent. Allowing people to buy antibiotics when they feel it is appropriate is a far different animal and liable to do more good than harm. The usage will be diffuse and unlikely to lead to resistant strains.
- archgoon 6y ago> A similar scenario is sceen in India where most antibiotics are available OTC, something "unthinkable" in the US. That seems very dangerous, and extremely bad public health policy. There are major concerns with anti-biotic resistant bacteria. I came across an article from 2017 suggesting the government clamped down on this. Is it still the case that anti-biotics can be purchased without prescription? https://www.outsourcing-pharma.com/Article/2017/01/16/Indian-clamps-down-on-OTC-antibiotic-sales-to-stem-spread-of-superbugs https://www.outsourcing-pharma.com/Article/2017/01/16/Indian... Also, I'm confused, I can easily buy over the counter Vitamin D supplements in the US. Is the dosage of those not large enough?
- dmix 6y agoI take 5 of the 'normal' dosage Vitamin D after watching reading heavily into the topic when it was making the rounds when COVID came about. One that got me into it was Rogan's interview on the subject (whom as an individual I don't generally looking to a source for health advice, but the person being interviewed seems legit and my after-the-fact research seems to back this up): https://www.youtube.com/watch?v=tBSfIckPV44 https://www.youtube.com/watch?v=tBSfIckPV44 So I'm assuming the dosages are too low. But so are most 'natural' supplements. Edit: this is the HN comment link for OP's mentioned "Shannon's Story" article https://news.ycombinator.com/item?id=24261948 https://news.ycombinator.com/item?id=24261948
- bitwize 6y agoFor everyone's info, "normal" dosage is 25 μg, or 1000 IU per pill.
- dmix 6y agoYes, sorry I didn't have the bottle on hand to mention the dose. I'm going for 5000IU (the dose that the Shannon person in the article was taking for supplementation). All the bottles at my pharmacy were 1000IU so I just bought one of them and take 5 of them. I was surprised to read in the article (and elsewhere) that 5000IU doses was mentioned as a common OTC dose as I couldn't find it. But I live in Canada so maybe it's different.
- hammock 6y ago5000IU is the dose that most Vit D supplements come in.. its just a tiny little gelcap. And it's extremely accessible, you can get it in any drug store or online for not very much money.
- moonbug 6y ago> Beware of that author's potential biases: doctors are heavily invested in getting you to pay them more The US is not the rest of the world.
- ta988 6y agoCholecalciferol, vitamin d3 is 384.648 g·mol−1. So 1 nmol/L is 384.649 ng/L or 0.384649 ng/mL. Also, 1 IU is 0.025 µg.