The heavy lifting in Python is usually happening in CFFI, so even if your Python house is completely in order you're still on the hook for having the just-right

The heavy lifting in Python is usually happening in CFFI, so even if your Python house is completely in order you're still on the hook for having the just-right versions of C libraries like 'libxml2' installed. There's a good chance that upstream development is happening against bleeding-edge libraries that were installed via homebrew, so if you're developing or deploying to anything not-Darwin you can expect a bumpy ride.