The paper Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmi

The paper Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients [1]: > Only four genera (Prevotellaceae, Faecalibaculum, Lachnospiraceae and Ruminococcaceae) were found to be significantly differentially abundant which impacts brain function: > Subsequent protein network analyses highlighted several differentially expressed proteins in the hippocampus of adult mice that received microbiota from aged donors compared to adult mice that received microbiota from age-matched adult donors. which implies the involvement of cellular signalling. Interestingly: > although major alterations of the blood-brain barrier (BBB) components were not detected, we observed a downregulation of proteins involved in glucose transport across the BBB... that might contribute to the dysfunctional bioenergetic system of the ageing brain [1] https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00914-w https://microbiomejournal.biomedcentral.com/articles/10.1186...