Conclusions: A-LCD (low carbohydrate diet) could exert a beneficial effect on depression and glycometabolism in patients with T2DM. We speculate that the role o

Conclusions: A-LCD (low carbohydrate diet) could exert a beneficial effect on depression and glycometabolism in patients with T2DM. We speculate that the role of a-LCD in improving depression in patients with T2DM may be associated with it stimulating the growth of SCFAs-producing bacteria, increasing SCFAs production and GPR43 activation, and further maintaining GLP-1 secretion. In future studies, the SCFAs and GPR43 activation should be further examined.