4 ms·

So, on average, 200ish times the recommended daily dose? No wonder she had problems.

voisin 6y ago
Agreed, but her problems resolved within 6 months and VitD returned to normal within 18. Quite a difference from the doctor here on HN that has been claiming irreversible issues from taking doses far below what this lady took.
- beervirus 6y ago
  Hard to draw many conclusions from a sample size of 1, other than that taking megadoses is a bad idea.
- PragmaticPulp 6y ago
  Don’t mistake the remission of serious, life-threatening anomalies in this one patient as evidence that no long-term damage was done. In these cases, the doctors aren’t giving the patient a clean bill of health across all parameters. They’re just confirming that the immediately life threatening issues are no longer an imminent danger to the patient. It’s entirely likely that the patient suffered more insidious, long-term health consequences that aren’t immediately obvious. It should also go without saying that the excessive vitamin D doses didn’t do her any favors. The “more is better” approach to vitamins in the alternative medicine community really needs to stop.
aaron695 6y ago
I think 130 times recommended. Or perhaps only 30 times what should be recommend. It's thought the old recommended dose is to low for some people or some situations. Which is why they really want to push it up as much as possible for all because it will save lives. Hence these studies. I'm doing 1000UI daily given current data and covid-19.
- arkitaip 6y ago
  I seriously doubt this was a scientific study to test the upper tolerance limits of vit D. I mean, no ethics committee on the planet would approve the dosage.
  - phobosanomaly 6y ago
    I was hoping to see an animal model, or on an in-vitro model: Bao YW, Yuan Y, Chen JH, Lin WQ. Kidney disease models: tools to identify mechanisms and potential therapeutic targets. Zool Res. 2018;39(2):72-86. doi:10.24272/j.issn.2095-8137.2017.055 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885387/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885387/ Nishinakamura, R. Human kidney organoids: progress and remaining challenges. Nat Rev Nephrol 15, 613–624 (2019). https://doi.org/10.1038/s41581-019-0176-x https://doi.org/10.1038/s41581-019-0176-x https://www.nature.com/articles/s41581-019-0176-x#citeas https://www.nature.com/articles/s41581-019-0176-x#citeas With a nice, simple graph showing effects of Vitamin D levels on kidney function over time.

Agreed, but her problems resolved within 6 months and VitD returned to normal within 18. Quite a difference from the doctor here on HN that has been claiming irreversible issues from taking doses far below what this lady took.

beervirus 6y ago
Hard to draw many conclusions from a sample size of 1, other than that taking megadoses is a bad idea.
PragmaticPulp 6y ago
Don’t mistake the remission of serious, life-threatening anomalies in this one patient as evidence that no long-term damage was done. In these cases, the doctors aren’t giving the patient a clean bill of health across all parameters. They’re just confirming that the immediately life threatening issues are no longer an imminent danger to the patient. It’s entirely likely that the patient suffered more insidious, long-term health consequences that aren’t immediately obvious. It should also go without saying that the excessive vitamin D doses didn’t do her any favors. The “more is better” approach to vitamins in the alternative medicine community really needs to stop.

aaron695 6y ago

I think 130 times recommended. Or perhaps only 30 times what should be recommend. It's thought the old recommended dose is to low for some people or some situations. Which is why they really want to push it up as much as possible for all because it will save lives. Hence these studies. I'm doing 1000UI daily given current data and covid-19.

arkitaip 6y ago
I seriously doubt this was a scientific study to test the upper tolerance limits of vit D. I mean, no ethics committee on the planet would approve the dosage.
- phobosanomaly 6y ago
  I was hoping to see an animal model, or on an in-vitro model: Bao YW, Yuan Y, Chen JH, Lin WQ. Kidney disease models: tools to identify mechanisms and potential therapeutic targets. Zool Res. 2018;39(2):72-86. doi:10.24272/j.issn.2095-8137.2017.055 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885387/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885387/ Nishinakamura, R. Human kidney organoids: progress and remaining challenges. Nat Rev Nephrol 15, 613–624 (2019). https://doi.org/10.1038/s41581-019-0176-x https://doi.org/10.1038/s41581-019-0176-x https://www.nature.com/articles/s41581-019-0176-x#citeas https://www.nature.com/articles/s41581-019-0176-x#citeas With a nice, simple graph showing effects of Vitamin D levels on kidney function over time.