6 ms·
What's missing for reseting all / most of the DNA from an organ/a whole body in mammals?? Just reseting the DNA repair section of the DNA of a whole organ would
by The_rationalist 6y ago
What's missing for reseting all / most of the DNA from an organ/a whole body in mammals??
Just reseting the DNA repair section of the DNA of a whole organ would enable massively slowing the ageing/cancer risks of said organ/body!
It is the key towards rejuvenation and preventing cancer, heizeimer and most diseases!
I can't find a good resource on why this is not currently possible and where can I track scientific incremental progress towards making this breakthrough a reality, which would then become the biggest technological progress of the 21 century!
Why aren't an enormous amount (and diluted over days or months) of viral vectors enough?
https://en.m.wikipedia.org/wiki/Viral_vector#:~:text=Viral%20vectors%20are%20tools%20commonly,inside%20the%20cells%20they%20infect https://en.m.wikipedia.org/wiki/Viral_vector#:~:text=Viral%2....
- flobosg 6y agoDon't underestimate the complexity of biological systems. https://en.wikipedia.org/wiki/Gene_therapy#Hurdles https://en.wikipedia.org/wiki/Gene_therapy#Hurdles
- haihaibye 6y agoYou have trillions of cells, each that contain billions of bases. Each cell can go wrong in its own way, and what you have to patch it back to is different for every person All of these steps are currently not possible: * establish a perfect sequence for an individual * find mutations non-destructively (ie cell survives) * send a specific edit to a specific cell in live animal * perform just that modification (see https://en.m.wikipedia.org/wiki/Off-target_genome_editing https://en.m.wikipedia.org/wiki/Off-target_genome_editing)