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People would eat variable amounts of grapefruit and might not eat it every day. Medications also have the potential to become toxic and have other effects other
by xattt 6y ago
People would eat variable amounts of grapefruit and might not eat it every day. Medications also have the potential to become toxic and have other effects other than the therapeutic effect.
Can you imagine trying to explain this concept to an elderly family member? A blanket statement is easier to comprehend for the general population.
People DO take insulin where the med is adjusted based on the blood sugar, but this is often accompanied with diabetic education component that takes weeks to complete.
- hinkley 6y agoI have wondered though why no time release formulations increase longevity by including a small amount of the active ingredient of grapefruit. Likely due to the other interactions besides metabolism, like cardiac function.
- xattt 6y agoSome antibiotics DO have adjuvants that prolong excretion. Examples are probenecid that was added to penicillin formulations to ensure there was enough supply. Imipenem (another antibiotic) is given with cilastin to reduce clearing of the drug by the kidney. Patients get into trouble when their renal clearance is already poor from long-standing kidney disease, so the potential is there for the drug to build to a level where it exhibits effects beyond its therapeutic intent (ie toxicity).
- Talanes 6y agoThe diabetes case is also most commonly accomplished with constant rapid testing. I don't think anybody loves grapefruit enough to bleed for it.