4 ms·
The drug-discovery venture I lead goes into some detail on grapefruit, hesperidin, and naringin in context of drug interactions at the end of this article in Me
by ricksunny 6y ago
The drug-discovery venture I lead goes into some detail on grapefruit, hesperidin, and naringin in context of drug interactions at the end of this article in Medium’s An Idea publication (just scroll
to the graphic from the FDA):
https://medium.com/an-idea/enter-flavonoids-f42662810c11 https://medium.com/an-idea/enter-flavonoids-f42662810c11
Conventionally was thought that the main culprit was bergamotin; but subsequent research showed that naringin (citrus in general but grapefruit especially) and hesperidin (citrus
in general - orange, lime, lemon) have their own important interactions with drug-metabolizing enzymes.
- ricksunny 6y ago[Here is a link straight to the academic paper on naringin / hesperidin on the human OATP1A2 human medicine-processing enzyme (so you can skip having to find the link in the above Medium article): https://pubmed.ncbi.nlm.nih.gov/17301733/ https://pubmed.ncbi.nlm.nih.gov/17301733/ ] Flavonoids are a unique class of plant-derived compounds; They can bind a lot of things - in some cases that's bad according to some med chemists, and some cases its good according to other med chemists . . .