4 ms·
Being a little pedantic, the drug interactions part of the article applies to bitter citrus specifically: not just grapefruit (despite the title!), but not all
by strogonoff 6y ago
Being a little pedantic, the drug interactions part of the article applies to bitter citrus specifically: not just grapefruit (despite the title!), but not all citrus either. Typically “orange” is used to refer to sweet oranges, not sour oranges.
As to soda, I struggle to imagine a soda that has any amount of juice worth taking into account…
- simonh 6y agoSodas often contain significant amounts of ciric or phosphoric acid.
- deleted 6y ago[deleted]
- thw0rted 6y agoPer the article, the drug-interaction problem comes from furanocoumarins depleting your cytochrome P450. There's nothing in there to suggest that refined acid (as opposed to unprocessed juice) would include furanocoumarins.
- schwartzworld 6y agoOrangina?
- xtracto 6y agoI once read that CocaCola is the largest consumer of lemon oil in the world. So I am sure their syrup has plenty of it.
- kingbirdy 6y agoI don't think this logic tracks - there are so many Cokes produced annually that even if every can had only 0.1 mL of lemon oil they'd still probably be the largest consumer.
- llarsson 6y agoNot too mention that the Coca-Cola company also own a staggering amount of more or less known brands, the bigger of which of course being Sprite and Fanta, which are likely large consumers of lemon oil.
- mlyle 6y agoFresca is right on the line, with a can shown to increase serum concentrations of some drugs by 50%--- not enough to matter in most cases.
- chimeracoder 6y ago> As to soda, I struggle to imagine a soda that has any amount of juice worth taking into account… It's not just the juice. The acidity level of your stomach affects absorption of many drugs - some are absorbed faster in an acidic environment and some are absorbed slower, which means drinking even Coca Cola (pH: 2.5) with your medication could potentially have the effect of negating your medication or increasing the effective dosage substantially, depending on the drug.
- et2o 6y agoYour stomach is already much more acidic than Coca Cola
- refurb 6y agoIndeed. It’s typically a pH of 1. And your body is really good at buffering acids and bases. Once your stomach empties into your small intestine, bicarbonate is released which raises the pH to around 5.5 I believe which is necessary for digestive enzymes to work.
- skunkworks 6y agoThink you'd be surprised. Coke pH is 2.5, and it seems that ideal human stomach pH is 1.5 to 2.5. Fun fact: you can use Coke to clean your toilets.