Thanks for this follow-up, I did more research and came across this information [0] on Wikipedia. I am not aware of how anyone would be able to give a guarante

Thanks for this follow-up, I did more research and came across this information [0] on Wikipedia. I am not aware of how anyone would be able to give a guarantee on duration of action. I'm not a doctor, so this could simply be naivety, but how could they possibly make the claim about how long the medicine would work, when all they know is how long the drug takes on average to be ingested and secreted from the patient's system? In my personal experience, I have never been able to feel the effects of opioid medicines as long as the prescribing doctor said to space out doses. Though I have never been prescribed OxyContin or anything that powerful, I fail to see how requiring companies to "guess at" things like this is anything beyond a way to scapegoat a company post-approval when the FDA finds it convenient. [0] https://en.wikipedia.org/wiki/Oxycodone#Duration_of_action https://en.wikipedia.org/wiki/Oxycodone#Duration_of_action