3 ms·

> From what I've read, Oxycontin was the first available drug that could be easily administered at home once or twice a day There are other opioids with extend

> From what I've read, Oxycontin was the first available drug that could be easily administered at home once or twice a day There are other opioids with extended release formulas, including morphine - they are nothing new. One of the major problems with OxyContin was that they lied about how long the effects lasted. From memory, they claimed up to 12 hours, and insisted you shouldn't take it more than twice a day. This turned out to be BS, with patients reporting it lasted for 6-8 hours max - just the same as other extended-release opioid formulations.

AndrewUnmuted 6y ago
That wasn't a lie. Tolerance is an issue with any narcotic medicine - from amphetamines to opiates. Many patients, whether they take Oxycontin or Vyvanse, will eventually complain that their tolerance will make that claim untrue. It doesn't mean the chemical isn't in their system.
- GordonS 6y ago
  Tolerance is a separate issue than the one I brought up. The issue of lying about the length of action is not related to tolerance - even patients new to OxyContin complained. I was prescribed OxyContin myself for a while, and know very well that it only works around 6 hours for me, just the same as other ER opioids.
  - AndrewUnmuted 6y ago
    Thanks for this follow-up, I did more research and came across this information [0] on Wikipedia. I am not aware of how anyone would be able to give a guarantee on duration of action. I'm not a doctor, so this could simply be naivety, but how could they possibly make the claim about how long the medicine would work, when all they know is how long the drug takes on average to be ingested and secreted from the patient's system? In my personal experience, I have never been able to feel the effects of opioid medicines as long as the prescribing doctor said to space out doses. Though I have never been prescribed OxyContin or anything that powerful, I fail to see how requiring companies to "guess at" things like this is anything beyond a way to scapegoat a company post-approval when the FDA finds it convenient. [0] https://en.wikipedia.org/wiki/Oxycodone#Duration_of_action https://en.wikipedia.org/wiki/Oxycodone#Duration_of_action
Balgair 6y ago
Aside: To Kill a Mockingbird famously had the character of Mrs. Henry Lafayette Dubose, a virulently racist morphine addict. Despite Mrs. Dubose's hatred of Atticus, he calls her the bravest person he ever knew. This is due to her resolve to break her addiction before her death, likely a horrifically painful experience due to her terminal cancer. In a book chock full of memorable people and events, these scenes still speak across the decades as the US struggles with the damnable effects of the Sacklers' unmitigated avarice. The book remains a must read to this day. https://en.wikipedia.org/wiki/List_of_To_Kill_a_Mockingbird_characters#Mrs._Henry_Lafayette_Dubose https://en.wikipedia.org/wiki/List_of_To_Kill_a_Mockingbird_...

AndrewUnmuted 6y ago

That wasn't a lie. Tolerance is an issue with any narcotic medicine - from amphetamines to opiates. Many patients, whether they take Oxycontin or Vyvanse, will eventually complain that their tolerance will make that claim untrue. It doesn't mean the chemical isn't in their system.

GordonS 6y ago
Tolerance is a separate issue than the one I brought up. The issue of lying about the length of action is not related to tolerance - even patients new to OxyContin complained. I was prescribed OxyContin myself for a while, and know very well that it only works around 6 hours for me, just the same as other ER opioids.
- AndrewUnmuted 6y ago
  Thanks for this follow-up, I did more research and came across this information [0] on Wikipedia. I am not aware of how anyone would be able to give a guarantee on duration of action. I'm not a doctor, so this could simply be naivety, but how could they possibly make the claim about how long the medicine would work, when all they know is how long the drug takes on average to be ingested and secreted from the patient's system? In my personal experience, I have never been able to feel the effects of opioid medicines as long as the prescribing doctor said to space out doses. Though I have never been prescribed OxyContin or anything that powerful, I fail to see how requiring companies to "guess at" things like this is anything beyond a way to scapegoat a company post-approval when the FDA finds it convenient. [0] https://en.wikipedia.org/wiki/Oxycodone#Duration_of_action https://en.wikipedia.org/wiki/Oxycodone#Duration_of_action

Balgair 6y ago

Aside: To Kill a Mockingbird famously had the character of Mrs. Henry Lafayette Dubose, a virulently racist morphine addict. Despite Mrs. Dubose's hatred of Atticus, he calls her the bravest person he ever knew. This is due to her resolve to break her addiction before her death, likely a horrifically painful experience due to her terminal cancer. In a book chock full of memorable people and events, these scenes still speak across the decades as the US struggles with the damnable effects of the Sacklers' unmitigated avarice. The book remains a must read to this day. https://en.wikipedia.org/wiki/List_of_To_Kill_a_Mockingbird_characters#Mrs._Henry_Lafayette_Dubose https://en.wikipedia.org/wiki/List_of_To_Kill_a_Mockingbird_...