4 ms·

Nice to have such a steady access to psilocybin. Why not LSD, by the way? > I've been microdosing psilocybin daily for the past six months, [...] I didn't get

by dmos62 6y ago

Nice to have such a steady access to psilocybin. Why not LSD, by the way? > I've been microdosing psilocybin daily for the past six months, [...] I didn't get COVID. Made me laugh.

emteycz 6y ago
Isn't the tolerance to LSD built way too fast for daily (micro)usage over half a year?
- teataster 6y ago
  Yes, same as psilocybin. When you microdose you are not supposed to get psychedelic effects. The supposed benefits come from prolonged presence of the molecule in the body. Similar how antidepressants work, the point is not to take one tablet once.
  - WalterSear 6y ago
    The effects of microdosing begin on consumption and end on discontinuation. They do not build up and fade slowly. Tolerance and breaks are frequently discussed. So, it's not about the effect of a prolonged presence.
- quantumwoke 6y ago
  Not sure what other people are using, but I've worked up to about 64mcg/day.
  - NeutronStar 6y ago
    100mcg is usually a full dose. Usually micrososing is 1/10th of a typical full dose so 10mcg. Your tolerance is already quite high if you're at 64mcg/day and not actively feeling any tripping.
dkersten 6y ago
> Why not LSD At least this [1] suggests that LSD microdosing doesn’t do anything, while there have been a few studies that suggested psilocybin micrososing does. Dunno how strong the evidence is in either direction but that would make me more inclined to start with psilocybin if I were to experiment myself. [1] https://www.gwern.net/LSD-microdosing#conclusion https://www.gwern.net/LSD-microdosing#conclusion
- dmos62 6y ago
  I can testify that LSD microdosing does something.
  - dkersten 6y ago
    Something that couldn’t also be accounted for by placebo? I guess it’s impossible to properly control for that in a non-blind test. What kind of effect are you experiencing and how strong (if you don’t mind)?
andai 6y ago
Easier to grow in the cupboard :)

by dmos62 6y ago

Nice to have such a steady access to psilocybin. Why not LSD, by the way? > I've been microdosing psilocybin daily for the past six months, [...] I didn't get COVID. Made me laugh.

emteycz 6y ago

Isn't the tolerance to LSD built way too fast for daily (micro)usage over half a year?

teataster 6y ago
Yes, same as psilocybin. When you microdose you are not supposed to get psychedelic effects. The supposed benefits come from prolonged presence of the molecule in the body. Similar how antidepressants work, the point is not to take one tablet once.
- WalterSear 6y ago
  The effects of microdosing begin on consumption and end on discontinuation. They do not build up and fade slowly. Tolerance and breaks are frequently discussed. So, it's not about the effect of a prolonged presence.
quantumwoke 6y ago
Not sure what other people are using, but I've worked up to about 64mcg/day.
- NeutronStar 6y ago
  100mcg is usually a full dose. Usually micrososing is 1/10th of a typical full dose so 10mcg. Your tolerance is already quite high if you're at 64mcg/day and not actively feeling any tripping.

dkersten 6y ago

> Why not LSD At least this [1] suggests that LSD microdosing doesn’t do anything, while there have been a few studies that suggested psilocybin micrososing does. Dunno how strong the evidence is in either direction but that would make me more inclined to start with psilocybin if I were to experiment myself. [1] https://www.gwern.net/LSD-microdosing#conclusion https://www.gwern.net/LSD-microdosing#conclusion

dmos62 6y ago
I can testify that LSD microdosing does something.
- dkersten 6y ago
  Something that couldn’t also be accounted for by placebo? I guess it’s impossible to properly control for that in a non-blind test. What kind of effect are you experiencing and how strong (if you don’t mind)?

andai 6y ago

Easier to grow in the cupboard :)