This is the most optimistic response to mistakes I have ever read, yet I kept hearing all of these other factors in my mind. Yes, get yourself back up, realize

This is the most optimistic response to mistakes I have ever read, yet I kept hearing all of these other factors in my mind. Yes, get yourself back up, realize your mistake, but if your situation does not change (neighborhood, job, disability) are you doomed to repeat? What are some alternatives to these that might be applicable to everyone?