Especially for routine computer use, I just swap my mouse to the other side of the keyboard and use my non-dominant hand. It takes a bit of getting used to, but

Especially for routine computer use, I just swap my mouse to the other side of the keyboard and use my non-dominant hand. It takes a bit of getting used to, but I can mouse with either hand pretty seamlessly unless I'm gaming. It really helps with wrist issues. I also prefer a split keyboard.