2 ms·
> After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient morta
by alextheparrot 6y ago
> After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage
Here's the key sentence from the study results. They are claiming a significant association [0] between Vitamin D above and below a threshold [1] and clinical severity [2]. The word "getting" is a bit deceptive, because "getting enough" tends to be in reference to their base behavior. Eating fruit helps me get enough vitamin C, so a doctor might recommend adjusting my behavior if tests show I have vitamin C deficiency. Adjusting my behavior would hopefully result in me "getting enough".
This is pretty different when compared to the study showing treatment results from Spain (Per another commenter) [3]. Here's the key conclusions from that study:
> Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19. Calcifediol seems to be able to reduce severity of the disease, but larger trials with groups properly matched will be required to show a definitive answer.
Treatment (Administration) with a chemical known to modulate the Vitamin D system now shows a clinical effect (ICU treatment reduction, albeit they have some reservations about study size). There's a whole set of further study that would need to be done to directly prove that the mechanism of action is exactly what they think it is, but it provides another good checkpoint (And is at the right abstraction layer to start considering it as a treatment more generally).
[0] Correlated, with the implication it could be worth studying as a causative driver
[1] "Sufficiency" is just a way of saying the assayed value is at least a value determined to be healthy
[2] They've got a long list of different clinical conditions they saw in the two cohorts
[3] https://www.sciencedirect.com/science/article/pii/S0960076020302764 https://www.sciencedirect.com/science/article/pii/S096007602...
- pmiller2 6y ago> ...serum levels of C-reactive protein (CRP).... This is interesting to me. I know C-reactive protein is an important biomarker of inflammation, but I've never seen anything that indicates lowering CRP actually does anything. What I have seen is that interventions like exercise and statins lower CRP, and improve other markets of cardiovascular health. One other interesting tidbit is this study [0], which suggests that vitamin D levels are inversely correlated with CRP levels, independently of COVID-19. This suggests to me that maybe the observed lower CRP levels in the COVID-19 patients might be a red herring. --- [0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492676/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492676/