3 ms·
One of the things not mentioned about bexarotene is that it's very teratogenic. That makes it more difficult (but not impossible) to use it for women. > Materi
by DanBC 6y ago
One of the things not mentioned about bexarotene is that it's very teratogenic. That makes it more difficult (but not impossible) to use it for women.
> Materials to support the Pregnancy Prevention Programme in women and girls of childbearing potential taking oral acitretin, alitretinoin, or isotretinoin have been updated. Oral tretinoin and bexarotene do not have a Pregnancy Prevention Programme in light of their oncology indication and specialist care setting. However, healthcare professionals are advised that these medicines are extremely teratogenic and product information should be consulted for contraceptive and pregnancy testing requirements when used in females of childbearing potential.
When used for cancer these side effects are very common (greater than 1 in 10) or common (between 1 in 10 and 1 in 100). Some of these are going to be mild and temporary. But some of them are serious.
> Alopecia; anaemia; appetite decreased; arthralgia; asthenia; chills; constipation; deafness; diarrhoea; dizziness; dry eye; dry mouth; dyslipidaemia; eye disorders; gastrointestinal discomfort; gastrointestinal disorders; headaches; hyperhidrosis; hypersensitivity; hypoproteinaemia; hypothyroidism; increased risk of infection; insomnia; leucopenia; lymphadenopathy; muscle complaints; nausea; oedema; oral disorders; pain; pseudolymphoma; sensation abnormal; skin nodule; skin reactions; skin ulcer; thyroid disorder; vomiting; weight changes