3 ms·
Layman here. I can't find a report about this clinical trial, maybe I didn't try hard. It is a phase II, in a phase II the goal is not to test the efficacy of
by JPLeRouzic 6y ago
Layman here. I can't find a report about this clinical trial, maybe I didn't try hard.
It is a phase II, in a phase II the goal is not to test the efficacy of the drug, it is to test the presence or absence of side effects.
A phase III role is needed to test if the drug is helpful to patients. It involves several hundred people to avoid statistical errors. Here there will be no phase III trial.
Another thing is that nerves can repair in the peripheral nervous system (PNS), but (until now) not in the central nervous system (CNS). If a drug can help nerves to repair in the CNS, it is certainly something revolutionary.
- JPLeRouzic 6y agoActually there is a recent publication which hints that bexarotene reduced the number of pro-inflammatory microglia/macrophages while increased the number of anti-inflammatory microglia/macrophages in mice: https://pubmed.ncbi.nlm.nih.gov/32916173/ https://pubmed.ncbi.nlm.nih.gov/32916173/