I'm very anti-prohibition and I also agree. I've tried very hard to come up with a justification to allow unbounded access to the "nasty ones": meth, fent, hero

I'm very anti-prohibition and I also agree. I've tried very hard to come up with a justification to allow unbounded access to the "nasty ones": meth, fent, heroin, and possibly coke/crack and xanax. What sets these apart? Their rapid delivery and extreme affinity for hitting reward pathways makes them chemically addicting almost by their nature. Further, they have narrow pharmacological windows, making overdose common. Ironically, if you look at the data blinded, without knowing the drug associated with the data point, alcohol _squarely_ belongs in this group. However there are plenty of entries safer than these drugs, that are far easier targets for legalization first.