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Actually if they know the mechanism of action and receptor that it affects, they can run computer simulations of thousands of chemicals quickly. This method of
by TheAdamAndChe 6y ago
Actually if they know the mechanism of action and receptor that it affects, they can run computer simulations of thousands of chemicals quickly. This method of simulating the 5-HT receptors was used to find 25i-NBOMe, an extremely powerful serotonin receptor agonist.
- epmaybe 6y agoI think people assume that drug development is still slow. For many targets, the time from discovery to market is around 6-7yrs (per a big pharma VP I spoke to a few years ago)
- whymauri 6y agoBut when drug discovery is a 4-6 year endeavor, knowing your site-of-action better and starting from a well-characterized template is worth its weight in gold. Edit: I realize this might not be clear, but drug discovery is a separate paradigm from drug development. So, together they take around 10-13 years.
- gavinray 6y agoThe entire 25x-NBOMe series was an unfortunate find (sociologically). Lot of people seemed to have a bad time on them. That was David Nichols' lab at Purdue IIRC. I also believe that they had found other, even more potent derivatives, but refused to publish them for fear they would be used as chemical weapons. The report had claimed activity at something like 1-10mcg range, which is real spooky when you consider the impact aerosolizing that could have on a room.
- TheAdamAndChe 6y agoWell unlike LSD which is a partial agonist, 25i-NBOMe is a full, irreversible agonist that can be lethal in the event of an overdose. It really wasn't designed for use as a recreational drug. It's history of discovery (as well as the 2C variants) was extremely interesting though.