5 ms·

(pre-rant: Why do people post medical articles on HN? If you say anything in response to them, you get downvoted because you're not a scientist/doctor/yada yada

by newobj 6y ago

(pre-rant: Why do people post medical articles on HN? If you say anything in response to them, you get downvoted because you're not a scientist/doctor/yada yada.) Having said that: people w/ MTHFR mutations are cautioned against nitrous during general anesthesia: https://www.scielo.br/scielo.php?pid=S0034-70942019000600637&script=sci_arttext https://www.scielo.br/scielo.php?pid=S0034-70942019000600637... https://pubmed.ncbi.nlm.nih.gov/18008117/ https://pubmed.ncbi.nlm.nih.gov/18008117/ It's funny, most people, even doctors, don't yet seem to know anything about MTHFR, but my son's dentist knew this (he has heterozygous mutations on 677 and 1298; I am homozygous 677) - so when I brought up MTHFR, she knew what to do - give him kiddie xanax rather than nitrous. I thought I was going to have to fight her about it, but nope. (also: i know this article is about local anesthesia, i'm making a more general comment about anesthetics and complications)

hackinthebochs 6y ago
How did you find out about the MTHFR mutation? Does it present with some visible symptoms such that a diagnosis will likely be made?
- bionhoward 6y ago
  Try a consumer genomics company like 23andme or nebula
PragmaticPulp 6y ago
Anything MTHFR-related has become a minefield of bad science on the internet. The amount of misinformation around the MTHFR gene is staggering, not to mention the droves of websites trying to sell various supplements and ebooks to people who are concerned about their MTHFR gene mutations. > Having said that: people w/ MTHFR mutations are cautioned against nitrous during general anesthesia: That's not exactly what those studies are saying. The latter is a single case report of an isolated incident which the authors hypothesized to be related to her rare homozygous MTHFR mutation. The former paper cites the latter paper as one of only two references. Needless to say, the evidence is quite weak. Moreover, the first paper recommends alternative methods that have their own downsides. It's remarkable that people are so quick to assume entire professions have overlooked something so obvious as the MTHFR mutation based on a pair of linked papers. In fact, the latter paper even goes so far as to say they are not advocating for removal of nitrous oxide nor for preemptive screening for the MTHFR mutation.
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by newobj 6y ago

hackinthebochs 6y ago

How did you find out about the MTHFR mutation? Does it present with some visible symptoms such that a diagnosis will likely be made?

bionhoward 6y ago
Try a consumer genomics company like 23andme or nebula

PragmaticPulp 6y ago

Anything MTHFR-related has become a minefield of bad science on the internet. The amount of misinformation around the MTHFR gene is staggering, not to mention the droves of websites trying to sell various supplements and ebooks to people who are concerned about their MTHFR gene mutations. > Having said that: people w/ MTHFR mutations are cautioned against nitrous during general anesthesia: That's not exactly what those studies are saying. The latter is a single case report of an isolated incident which the authors hypothesized to be related to her rare homozygous MTHFR mutation. The former paper cites the latter paper as one of only two references. Needless to say, the evidence is quite weak. Moreover, the first paper recommends alternative methods that have their own downsides. It's remarkable that people are so quick to assume entire professions have overlooked something so obvious as the MTHFR mutation based on a pair of linked papers. In fact, the latter paper even goes so far as to say they are not advocating for removal of nitrous oxide nor for preemptive screening for the MTHFR mutation.

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