My impression of spike attachment, via mediator, to the ACE2 is for cellular entry. I am not sure if this will exhaust the other ACE2 on other cells. That said

My impression of spike attachment, via mediator, to the ACE2 is for cellular entry. I am not sure if this will exhaust the other ACE2 on other cells. That said a saturation level of spike in the blood so all cells lose spike in all areas is very unlikely, as this would, in all certaintly, be lethal?? A full blown infection - does it ever reach the level of ACE2 exhaustion - or are there many cells no reached? Heart cells - death of many heart cells would be a problem?