3 ms·
As someone who cut his teeth on bioinformatics before eventually just completing a full computer science degree, I was a bit worried that this article wouldn’t
by alextheparrot 6y ago
As someone who cut his teeth on bioinformatics before eventually just completing a full computer science degree, I was a bit worried that this article wouldn’t address the applied scientific audience well. Pleasantly surprised, though, at how well this article evangelizes NumPy to that exact community.
Many labs are gaining access to or creating physical tools that create data analysis over experimental design problems. Biologists transitioning from running gels to detect the existence of a gene to running sequencing or flow cytometry to segment populations, for example. I remember seeing I think an RNA-seq experiment that tracked the full lineage of hematopoietic (blood) stem cells by a professor - my jaw was on the floor at the level of insight.
One remaining step is transitioning many bioinformatics courses from applied tooling to general program design and open-sourcing. I’ve noticed a few labs have done that really well for years, but it is not often found as a field-level skillset.
- rubatuga 6y agoThe coolest thing I read last year was about single cell rna-seq trajectory analysis of the differentiation for different blood cells.
- dm319 6y agoYou might like the mass cytometry reconstruction of the human haematopoietic system [1]. I've done a bit of scRNA-seq and mass cytometry, and the issue I have with scRNA-seq is the tiny dynamic range it has compared to flow/mass cytometry, which can make identifying populations much harder. Not to mention the cost! [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273988/figure/F2/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273988/figure/...