Let's say we can edit the human genome (CRISPR is not approved for human use), even then, there should extremely tight limits to our genomic editing, since for

Let's say we can edit the human genome (CRISPR is not approved for human use), even then, there should extremely tight limits to our genomic editing, since for the majority of the genome by sequence, expressed regions, and possibly still coding regions, has largely unknown function. We just don't understand so much of genomic function through evolutionary time from the simple fact that we cannot easily observe it, that making anything more than a SNP change is asking for major, unfixable problems at a population level down the line. If risk is (threat x vulnerability x consequence), we need to practice the utmost caution when that vulnerability period is the rest of our species existence!