So, according to the wiki, HFCS contains about 55% Fructose, 45% Glucose. Regular sucrose is at a 50-50 split. Given your stomach splits sucrose into the respec

So, according to the wiki, HFCS contains about 55% Fructose, 45% Glucose. Regular sucrose is at a 50-50 split. Given your stomach splits sucrose into the respective monosaccharide units anyway, you're going to end up with roughly the same amount of glucose and fructose floating around. The big issue then is just having a large amount of fructose (from whatever source) in your diet. Since excess fructose is shunted off to be stored as fat, this is what's causing all the problems. What would be kind of interesting is whether we can just go about engineering corn so that we block off the fructose pathway, and just produce glucose. This also has the nice side-effect that it's also much more delicious for bacteria to eat, meaning a greater yield of things like biofuels.