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If the false positive mechanism is contaminating one sample with another, the false positive rate will depend on the true positive rate in the samples that the
by cameldrv 6y ago
If the false positive mechanism is contaminating one sample with another, the false positive rate will depend on the true positive rate in the samples that the lab/testing site is processing. The other possibility would be if positive control amplicon contaminated the lab, which does happen.
- pps43 6y agoThe underlying assumption behind false positive rate is that tests are independent and identically distributed. If in practice this is not the case, then false positive rate becomes misleading.