Let's hope the situation is better now ;) A factor might also be what kind of mails you send. If it's important stuff for a specific user it make sense to have

Let's hope the situation is better now ;) A factor might also be what kind of mails you send. If it's important stuff for a specific user it make sense to have a direct reply. If you set a reply address to a newsletter with millions of subscribers the situation probably looks a bit different, especially when said sign up happens without much user input (i.e. "click here to also receive our newsletter").