Stage 1 and 2 trials establish safety in generally healthy people. Stage 3 is primarily to establish efficacy, but is also vital to establish safety in the broa

Stage 1 and 2 trials establish safety in generally healthy people. Stage 3 is primarily to establish efficacy, but is also vital to establish safety in the broader population, including among people with existing diseases. For their own safety, unhealthy people are not generally admitted into stage 1 and 2 trials. Curtailing stage 3 testing for political gain is dangerous.