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The issue is it stops viral transcription at levels that also happen to be lethal to humans :p
by ReflectedImage 6y ago
The issue is it stops viral transcription at levels that also happen to be lethal to humans :p
- amluto 6y agoMy recollection is that it stops viral replication in vitro in monkey cells but does not stop viral replication in vitro in human cells.
- acqq 6y agoYes, it just stops replication "within the glass" (that's the meaning of "in vitro") with the cell culture, not in living human patients, and even "within the glass" only when using the "the Vero E6 cell line which is derived from kidney cells of green monkeys." https://www.infectioncontroltoday.com/view/new-study-hydroxychloroquine-works-in-monkeys-not-humans https://www.infectioncontroltoday.com/view/new-study-hydroxy... "The mechanism of action of hydroxychloroquine is to block entry of the virus into cells. Viral entry requires a helper enzyme. In the Vero E6 cell line, this enzyme is cathepsin L which hydroxychloroquine blocks. However, in the human lung cell line, the helping enzyme is TMPRSS2. Hydroxychloroquine does not effectively block this enzyme and cellular entry of the virus occurs." So, inspired by the reports of the experiments with wrong cells a French doctor made some false claims about his success when treating patients, which were then promoted by one person wanting to be reelected, and then the followers... the results can be seen in the comments here.