> Besides clueless commentators on the Internet, who is suggesting depression is simply a matter of 'chemical imbalance'? If that were the case, it wouldn't be

> Besides clueless commentators on the Internet, who is suggesting depression is simply a matter of 'chemical imbalance'? If that were the case, it wouldn't be brought on by loneliness, and it wouldn't be treated with CBT and talking therapy. Most of (all?) chemical depression treatments are based on the serotoninergic depression hypothesis that has never been verified. In the recent years more and more arguments come directly against this hypothesis. Yet SSRIs are still the first line of treatment for depressive patients. https://en.wikipedia.org/wiki/Major_depressive_disorder#Pathophysiology https://en.wikipedia.org/wiki/Major_depressive_disorder#Path...