You picked the best title in the first sentence of your survey ;) I think something plain and to-the-point like 'JavaScript Web Applications' suits an O'Reilly

You picked the best title in the first sentence of your survey ;) I think something plain and to-the-point like 'JavaScript Web Applications' suits an O'Reilly publication, and gives a title a little bit more authority / respect. If you'd like to spice it up a little in the spirit of a Pragmatic Programmers / 37 Signals publication you might add something like 'Crafting' to the start of it: 'Crafting JavaScript Web Applications' Obviously that depends on the tone and spirit of your own work, but having seen your efforts over the years I'd imagine the whole passionate craftsman approach might work. However the chapters seem to lead up to 'The Realtime Web', and perhaps that's a catchphrase worth leveraging? 'Realtime JavaScript Web Applications' Perhaps the title's slightly long, but the book would be a lot more Googleable with the addition of 'realtime' judging by Google search results, but SEO's probably less of a worry, more a minor observation. Perhaps you could break it into title / subtitle? 'JavaScript Web Applications - Building for the Realtime Web' That's probably enough suggestions - your tweet just caught me in the morning with a good cup of tea :)