I agree, but I think there is a case to be made that there is important state separate from just which cells connect to which and how strongly, but is also more

I agree, but I think there is a case to be made that there is important state separate from just which cells connect to which and how strongly, but is also more coarse grained than single atoms floating around. The cytoskeleton may be found out to have a role to play. The number and locations of ion pumps. Or epigenetic changes in clusters of brain cells.