This is usually a hardware problem. I haven't found an easy way to detect if a GPU+monitor combination will have a very slow response time for DDC messages so a

This is usually a hardware problem. I haven't found an easy way to detect if a GPU+monitor combination will have a very slow response time for DDC messages so all I can do in Lunar is send the messages to the monitor and if a number of messages fail then Lunar stops sending them to keep the system usable. But there are cases like yours where the response time is so slow that the kernel panics in the first DDC message and freezes the whole system. There's no way to detect or recover from that in software.