3 ms·
The article mentions "reversibility" - what does it mean here? What kind of reversibility?
by akavel 6y ago
The article mentions "reversibility" - what does it mean here? What kind of reversibility?
- cowboysauce 6y agoIn this context irreversibility means that once the drug binds with its target, it's done. It can't unbind.
- projektfu 6y agoReversible means that there is an equilibrium of E + D <-> ED where E is enzyme and D is drug, and ED is the "complex" molecule. Irreversible binding looks like: E + D --> ED where the product on the right is effectively unable to become the molecules on the left again. An example of irreversible binding is COX-2 and aspirin.