3 ms·
Based on my understanding of immunology I don't think this peptide nasal spray is very likely to be an effective vaccine. In order to actually trigger an immune
by Metacelsus 6y ago
Based on my understanding of immunology I don't think this peptide nasal spray is very likely to be an effective vaccine. In order to actually trigger an immune response, the peptides would need to get taken up by cells and displayed on MHCs. I don't think simply spraying them into the nose will be good enough. It's an interesting idea but I think they should test it on animal models before dosing humans.
- jhou2 6y agoWell, I think they're trying to stimulate mucosal immunity, rather than trigger MHC presentation. But yes, more research is needed to determine effectiveness. "This highlights one important advantage of an intranasal vaccine: a robust mucosal immune response should greatly reduce or prevent this systemic response by abrogating initial infection."