But there’s quite a lot of research on this? Yes, the numerous studies and meta-analyses I’ve seen suggest an effect of between 1–10 years of healthy lifespan

But there’s quite a lot of research on this? Yes, the numerous studies and meta-analyses I’ve seen suggest an effect of between 1–10 years of healthy lifespan added. That’s certainly not nothing, but considering that life expectancy at birth is around 80 years in developed countries, you’re talking about something that represents 1/8 of that context. around your 40s is [...] when your body really starts to age hard I guess from a technical standpoint, you’re really ageing from birth. You certainly start to see the Gompertz curve start to bite in your 40s though, as the net metabolic damage starts to compound. Living longer, sure, but mostly it’s about living better I’ve never really understood this argument. Avoiding the diseases of ageing will ultimately lengthen your life. Avoiding them all indefinitely would lengthen your life almost indefinitely (there is still a non-zero risk of dying without ageing of course). Look, death and disease are scary. They’re existential threats. Focusing on diet and exercise is great fun, has a host of incidental benefits, and returns the locus of control to yourself; however it cannot do all that much to really deflect the asteroid of ageing in the long run. I just want people to be aware of what the magnitude of the effects actually are, and not get sucked into the hype machine. I suppose sometimes it’s better to travel hopefully than to arrive...I certainly hope that the state of the art advances fast enough to save us all, and that’s basically based on nothing. Supplements like Niacin are just a flat-out bust: https://www.cochrane.org/CD009744/VASC_niacin-people-or-without-established-cardiovascular-disease https://www.cochrane.org/CD009744/VASC_niacin-people-or-with... In fact, it’s highly improbable that any one oral drug or supplement will significantly alter the core pathology of ageing (and therefore reduce the risk of all age-related disease in one go). That’s because the human body is a highly complex, tightly-coupled system that is not designed to be reverse-engineered or modified, and because the soma and the germ line split so long ago.