3 ms·
Mouse models are just that. Models. A lot of the results in mice don't carry over to humans. A positive result in mice is only weakly indicative of potential ef
by moh_maya 6y ago
Mouse models are just that. Models. A lot of the results in mice don't carry over to humans. A positive result in mice is only weakly indicative of potential efficacy in humans. [1,2]
Pop-sci articles seldom acknowledge this or draw attention to this.
Re reservatol, the jury is really out on that one too. [3,4]
[1] https://theconversation.com/of-mice-and-men-why-animal-trial-results-dont-always-translate-to-humans-73354 https://theconversation.com/of-mice-and-men-why-animal-trial...
[2] https://www.nature.com/news/chilly-lab-mice-skew-cancer-studies-1.14190 https://www.nature.com/news/chilly-lab-mice-skew-cancer-stud...
[3] https://www.bostonmagazine.com/health/2019/10/29/david-sinclair/ https://www.bostonmagazine.com/health/2019/10/29/david-sincl...
[4] https://www.health.harvard.edu/blog/diet-rich-resveratrol-offers-health-boost-201405157153 https://www.health.harvard.edu/blog/diet-rich-resveratrol-of...
- tim333 6y agoYeah it's a bit hard to tell either way - works or does nothing much. The enthusiasts like Sinclair take DNA methylation tests which seem to indicate some effect but whether that translates to longer life I dunno. I've been too tight to try those as they tend to run $300 per test.