Expanding on this, oxytocin has many known (and likely unknown) purposes but is most closely associated with context dependent social bonding and exclusion, sex

Expanding on this, oxytocin has many known (and likely unknown) purposes but is most closely associated with context dependent social bonding and exclusion, sex, and childbirth. Somewhat coincidentally for the purposes of this conversation, it also inhibits chemical dependence (including opioids, which includes oxycontin and oxycodone). [1][2] [1] https://www.sciencedirect.com/science/article/pii/S0091305713002219 https://www.sciencedirect.com/science/article/pii/S009130571... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089904/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089904/ This concludes the reply relevant section of my comment. Sidenote (mostly me screaming into the void): due to excruciating constant chronic pain from a botched surgery, I took three oxycodone for 4 years (March 2015-August 2019) every single day. It enabled me to work and live a (greatly diminished) life. For all of the harm the crisis inflicted—and the Sacklers did great evil for great reward—there is really not another class of medication that would have kept me functioning. Fortunately for me, I managed to get a very good job with great healthcare and I immediately used that to have a corrective surgery with the best surgery center in the country. This took me from about 65% functional (medicated) to about 85% functional, unmedicated. That last 15% is never coming back, and I have to live with the fact a doctor permanently damaged my body in an uncorrectable way. But, over the course of my treatment, the backlash against opioids began to make it difficult for my pain management clinic to provide the treatment I needed even though I was completely compliant (and had the regular drug tests to prove it—so many cups of pee). I would be dead without opioids. I would have killed myself. There are many more like me who still suffer from unmanageable pain who either cannot get the medication they need. There are many people who are not here because of opioids as well so I completely understand the backlash, I just hope we don’t overcorrect. The Sacklers harm cannot be undone, but their reward can be—expropriate it all (leave them an apartment with running water and a roof so that it’s technically legal).