3 ms·

1. Not a low dose (400mg/week should be enough from what I've read) 2. No mention of zinc supplements, which seems to be the key to make the Hydroxychloroquine

1. Not a low dose (400mg/week should be enough from what I've read) 2. No mention of zinc supplements, which seems to be the key to make the Hydroxychloroquine effective

JumpCrisscross 6y ago
> No mention of zinc supplements, which seems to be the key to make the Hydroxychloroquine effective Clearly not.
- jbritton 6y ago
  To my knowledge there has not yet been a trial completed with HCQ+Zinc. There are several doctors stating positive observational results with HCQ+Zinc. I’m waiting for this study to complete: https://clinicaltrials.gov/ct2/show/NCT04370782 https://clinicaltrials.gov/ct2/show/NCT04370782 Zinc has antiviral properties. It has been shown to stop Sars Cov2 replication in-vitro. Cells limit their Zinc intake. HCQ facilitates Zinc getting into cells.
  - gojomo 6y ago
    Yes, it's been amazing to me how nearly everyone with continuing interest in HCQ has emphasized Zinc as an important factor, while so many studies have ignored it: neither supplementing it nor even checking enrolled patients for zinc deficiencies (which may be especially prevalent in the aged or those with known Covid comorbidities). So I'll see, for example, some otherwise-highly-credible UCSF researchers mention a bunch of evidence they think puts the potential of HCQ to help to rest, without any mention of Zinc considerations (even in passing, or to ridicule, or to share why they don't think the link credible). But even coincident upon the very 1st discussions of HCQ as having potential, Derek Lowe shared an anecdote about how carrying-Zinc seemed essential to Chloroquine-related-compoounds' bioactivity (https://blogs.sciencemag.org/pipeline/archives/2020/03/20/chloroquine-past-and-present https://blogs.sciencemag.org/pipeline/archives/2020/03/20/ch...). And, in many parts of the world, HCQ – as a cheap drug that, in moderate doses with proper monitoring, is very low-risk – is already considered part of the Covid-19 "standard-of-care". So, it's given even to the 'control' arms of trials for other compounds – making both its effects, and those other compounds' effects, harder to disentangle. All I want now is true randomized trials - and can't at least one of those monitor, or vary the supplementation of, Zinc as well?
  - lucd 6y ago
    A subgroup analysis by self-reported zinc usage was done in the post-exposure prophylaxis RCT . No effect. https://twitter.com/methodsmanmd/status/1293350242310590464 https://twitter.com/methodsmanmd/status/1293350242310590464
  - hhw 6y ago
    In vitro means a petri dish. Bleach has antiviral properties in those conditions. In vitro results are much less meaningful than in vivo results. It can be a useful early validation step, but is far from telling us anything about real world efficacy. There's enough in vivo studies at this point that in vitro studies should no longer be part of the conversation.
deleted 6y ago
[deleted]

1. Not a low dose (400mg/week should be enough from what I've read) 2. No mention of zinc supplements, which seems to be the key to make the Hydroxychloroquine effective

JumpCrisscross 6y ago

> No mention of zinc supplements, which seems to be the key to make the Hydroxychloroquine effective Clearly not.

jbritton 6y ago
To my knowledge there has not yet been a trial completed with HCQ+Zinc. There are several doctors stating positive observational results with HCQ+Zinc. I’m waiting for this study to complete: https://clinicaltrials.gov/ct2/show/NCT04370782 https://clinicaltrials.gov/ct2/show/NCT04370782 Zinc has antiviral properties. It has been shown to stop Sars Cov2 replication in-vitro. Cells limit their Zinc intake. HCQ facilitates Zinc getting into cells.
- gojomo 6y ago
  Yes, it's been amazing to me how nearly everyone with continuing interest in HCQ has emphasized Zinc as an important factor, while so many studies have ignored it: neither supplementing it nor even checking enrolled patients for zinc deficiencies (which may be especially prevalent in the aged or those with known Covid comorbidities). So I'll see, for example, some otherwise-highly-credible UCSF researchers mention a bunch of evidence they think puts the potential of HCQ to help to rest, without any mention of Zinc considerations (even in passing, or to ridicule, or to share why they don't think the link credible). But even coincident upon the very 1st discussions of HCQ as having potential, Derek Lowe shared an anecdote about how carrying-Zinc seemed essential to Chloroquine-related-compoounds' bioactivity (https://blogs.sciencemag.org/pipeline/archives/2020/03/20/chloroquine-past-and-present https://blogs.sciencemag.org/pipeline/archives/2020/03/20/ch...). And, in many parts of the world, HCQ – as a cheap drug that, in moderate doses with proper monitoring, is very low-risk – is already considered part of the Covid-19 "standard-of-care". So, it's given even to the 'control' arms of trials for other compounds – making both its effects, and those other compounds' effects, harder to disentangle. All I want now is true randomized trials - and can't at least one of those monitor, or vary the supplementation of, Zinc as well?
- lucd 6y ago
  A subgroup analysis by self-reported zinc usage was done in the post-exposure prophylaxis RCT . No effect. https://twitter.com/methodsmanmd/status/1293350242310590464 https://twitter.com/methodsmanmd/status/1293350242310590464
- hhw 6y ago
  In vitro means a petri dish. Bleach has antiviral properties in those conditions. In vitro results are much less meaningful than in vivo results. It can be a useful early validation step, but is far from telling us anything about real world efficacy. There's enough in vivo studies at this point that in vitro studies should no longer be part of the conversation.

deleted 6y ago

[deleted]