The odds favor Andromeda, yes. But depending on just how rare intelligent life is, there is some possibility that we have a lucky head start. As for fleeing: T

The odds favor Andromeda, yes. But depending on just how rare intelligent life is, there is some possibility that we have a lucky head start. As for fleeing: The whole concept of "fleeing" assumes a civilization composed of discrete beings that are expensive to reproduce but can be feasibly transported. The idea of Von Neumann probes is based on a different assumption. The probe itself is very small, maybe only a few pounds, but is designed to expand using the resources at its destination. There probably aren't discrete beings -- computers can freely exchange "memories" over networks which makes them effectively all one big hive mind. The hive mind directly controls everything it builds. Eventually the entire star system -- perhaps the entire galaxy or universe -- becomes effectively one giant intelligent being as all available resources are assimilated. This civilization would certainly send probes to neighboring galaxies if it has the ability to, but it makes no sense to think about transporting the "inhabitants" (if you can even call them that) of one star system to another en masse.