I think you need to rework your definitions. Avoid using the word proven. Most of the time science proves things false. You can't prove anything to be true. Th

I think you need to rework your definitions. Avoid using the word proven. Most of the time science proves things false. You can't prove anything to be true. The difference between a null and a negative is just that a negative is an interesting null. In your null example, to create a proper negative you'd probably report several compound synthesis methods instead of one. You'd probably also want to use more mice/data in your analysis.