3 ms·
This 2018 article rests on the assumption that Lewy bodies [1] are associated with a pathogen that begins in the gut and works its way into the brain via the va
by sradman 6y ago
This 2018 article rests on the assumption that Lewy bodies [1] are associated with a pathogen that begins in the gut and works its way into the brain via the vagus nerve. The way I read the cell biology section, Lewy bodies are the artefacts of a broken process in nerve/neuron cells.
It seems to me that the broken process is more likely to be senescence related than a pathogen caused disease that mainly manifests in the elderly.
Regardless, the main take-away I have is that chronic constipation without prior history may be an early symptom of Parkinson’s. This fits the senescence model as degraded nerve function in the gut will cause constipation just like opioids do.
[1] https://en.m.wikipedia.org/wiki/Lewy_body#Cell_biology https://en.m.wikipedia.org/wiki/Lewy_body#Cell_biology
- starfallg 6y agoI don't think anybody is discounting senescence being a factor, but rather theorising the likely pathology of the disease which may be a combination of different factors, including pathogens together with senescence.
- omgwtfbyobbq 6y agoChronic constipation is also associated with some neurotransmitter disorders that can predispose people to PD. In my experience, doctors are not able to distinguish between PD that's neurodegenerative or neurometabolic during a consult. In addition, GI issues can also complicate neurometabolic PD/Parkinsonism/etc, and I imagine it's difficult to differentiate the two without a thorough evaluation and genetic testing.