There are several proposed mechanisms to "enable" SPDY. The preferred is to run over SSL, and to use their NPN extension to negotiate SPDY support: http://tools

There are several proposed mechanisms to "enable" SPDY. The preferred is to run over SSL, and to use their NPN extension to negotiate SPDY support: http://tools.ietf.org/html/draft-agl-tls-nextprotoneg-00.html http://tools.ietf.org/html/draft-agl-tls-nextprotoneg-00.htm... Alternatively, there is work on sending an "upgrade" header in your regular HTTP response: http://code.google.com/p/chromium/issues/detail?id=69688 http://code.google.com/p/chromium/issues/detail?id=69688 The NPN route is obviously the best in terms of performance, since the protocol can be negotiated as part of the TLS handshake.. Long story short: you can definitely run your own SPDY server and Chrome will auto-detect and use the protocol.